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Adenosine Injection 6mg/2ml is a fast-acting prescription anti-arrhythmic medication primarily used to immediately terminate Paroxysmal Supraventricular Tachycardia (PSVT) and restore a normal heart rhythm. It is a sterile, clear solution containing a concentration of 3 mg of adenosine per mL. Because of its powerful mechanism and ultra-short biological half-life of less than 10 seconds, it is strictly classified as a hospital-only drug and must be administered by a healthcare professional. [1, 2, 3, 4, 5]

Primary Uses

  • Treating PSVT: It breaks the abnormal re-entry electrical circuits in the heart, safely reverting abnormally fast rhythms—including those associated with Wolff-Parkinson-White (WPW) syndrome—back to a normal sinus rhythm. [1, 2]

  • Diagnostic Tool: Doctors use it during pharmacologic cardiac stress tests to dilate coronary arteries and help identify heart disease when patients cannot perform regular exercise. [1, 2]

Administration Protocol

Adenosine requires a highly specific administrative protocol because it is cleared by blood cells almost instantly: [1, 2, 3, 4]

  1. Rapid IV Push: It is given as a rapid bolus over 1 to 3 seconds through an intravenous line close to the heart. [1, 2]

  2. Saline Flush: It must be followed immediately by a rapid flush of 20 mL normal saline to push the medicine into central circulation before it breaks down. [1, 2]

  3. Dose Escalation: If the initial 6 mg dose fails to correct the rhythm within 1 to 2 minutes, a second dose of 12 mg is typically administered. [1]

Safety, Interactions, and Side Effects

  • Dietary Restrictions: Patients must strictly avoid all caffeine and methylxanthines (such as coffee, tea, chocolate, and colas) for at least 12 hours prior to administration, as these substances competitively block the therapeutic effects of adenosine. [1, 2]

  • Common Side Effects: The drug commonly causes brief, transient sensations including facial flushing, chest tightness or pressure, dizziness, nausea, and short-lived heart blocks or skipped beats. These effects generally disappear within seconds to minutes. [1, 2, 3, 4, 5]

  • Contraindications: Adenosine should not be given to individuals suffering from certain advanced heart conditions, such as second- or third-degree heart blocks, unless a functional artificial pacemaker is present. [1]

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